ADENOSINE
Adenosine Injection, USP FOR RAPID BOLUS INTRAVENOUS USE
FULL PRESCRIBING INFORMATION: CONTENTS*
- ADENOSINE DESCRIPTION
- CLINICAL PHARMACOLOGY
- ADENOSINE INDICATIONS AND USAGE
- ADENOSINE CONTRAINDICATIONS
- WARNINGS
- PRECAUTIONS
- ADENOSINE ADVERSE REACTIONS
- OVERDOSAGE
- ADENOSINE DOSAGE AND ADMINISTRATION
- HOW SUPPLIED
FULL PRESCRIBING INFORMATION
ADENOSINE DESCRIPTION
CLINICAL PHARMACOLOGY
Mechanism of Action
Hemodynamics
Pharmacokinetics
mmaxClinical Trial Results
ADENOSINE INDICATIONS AND USAGE
Intravenous adenosine injection is indicated for the following.
Conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). When clinically advisable, appropriate vagal maneuvers (e.g., Valsalva maneuver), should be attempted prior to adenosine administration.
It is important to be sure the adenosine solution actually reaches the systemic circulation (see DOSAGE AND ADMINISTRATION).1
Adenosine injection does not convert atrial flutter, atrial fibrillation, or ventricular tachycardia to normal sinus rhythm. In the presence of atrial flutter or atrial fibrillation, a transient modest slowing of ventricular response may occur immediately following adenosine injection administration.
CONTRAINDICATIONS
- Second- or third-degree A-V block (except in patients with a functioning artificial pacemaker).
- Sinus node disease, such as sick sinus syndrome or symptomatic bradycardia (except in patients with a functioning artificial pacemaker).
- Known hypersensitivity to adenosine.
WARNINGS
Heart Block
Arrhythmias at Time of Conversion
Bronchoconstriction
e2PRECAUTIONS
Drug Interactions
WARNINGSWARNINGSCarcinogenesis, Mutagenesis, Impairment of Fertility
Pregnancy Category C
Pediatric Use
DOSAGE AND ADMINISTRATION1Geriatric Use
ADVERSE REACTIONS
Cardiovascular
Respiratory
Central Nervous System
Gastrointestinal
Post Marketing Experience (see WARNINGS)
Cardiovascular
Respiratory
Central Nervous System
OVERDOSAGE
DOSAGE AND ADMINISTRATION
Adenosine injection should be given as a rapid bolus by the peripheral intravenous route. To be certain the solution reaches the systemic circulation, it should be administered either directly into a vein or, if given into an IV line, it should be given as close to the patient as possible and followed by a rapid saline flush.
Adult Patients
Initial dose
Repeat administration
Pediatric Patients
Initial dose
Repeat administration
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Doses greater than 12 mg are not recommended for adult and pediatric patients.
CAUTION: Product-Connector Incompatibility Notice:
®
BD Q-SyteTM adaptor or other suitable adaptor are required for use with LADs such as CLAVE® systems.
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HOW SUPPLIED
DO NOT REFRIGERATE
Rx Only
REFERENCE
- Paul T, Pfammatter. J-P. Adenosine: an effective and safe antiarrhythmic drug in pediatrics. Pediatric Cardiology 1997; 18:118-126.
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Distributed by:
ADENOSINEADENOSINE INJECTION
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