CENTER-AL - ACACIA LONGIFOLIA POLLEN

ALK-Abello, Inc.

Alum Precipitated Extracts

FULL PRESCRIBING INFORMATION

DIRECTIONS FOR USE OF CENTER - AL® THERAPEUTIC

ALLERGENIC EXTRACTS ALUM PRECIPITATED

OF

POLLENS, HOUSE DUSTS, MOLDS,

INHALANTS AND EPIDERMALS

DOSAGE BASED ON

PROTEIN NITROGEN CONTENT

Center-Al^® (Allergenic extracts, Alum Precipitated) is prepared from aqueous allergenic extracts by the formation of an aluminum hydroxide precipitated complex. It is supplied as a sterile suspension in multiple dose vials for subcutaneous injection. 0.4% Phenol is added as a preservative.

This product is compounded and diluted on a PNU basis. Extracts containing Short Ragweed Pollen also bear a labeled potency declaration in terms of Antigen E content.

Numerous studies have confirmed Antigen E (AgE) as the major antigen associated with Short Ragweed pollinosis. In a well controlled study, purified Antigen E was significantly superior to placebo in amelioration of symptoms associated with Short Ragweed pollinosis.¹ Therefore, it is essential that the physician be aware of AgE content of allergenic extracts administered for hyposensitization therapy.

Some studies have indicated that for most patients a cumulative Antigen E dosage of less than 0.1 unit is not immunizing (sufficient to stimulate specific IgG antibodies).² This, however, does not suggest that a 0.1 unit is a maximum tolerated dose. Most moderately sensitive patients may tolerate a dosage ten to fifty times greater. For exquisitely sensitive patients who cannot tolerate an immunizing dose of this preparation, the physician should consider immunotherapy with alternatives to conventional aqueous allergenic extract.

Alum precipitated bacterial and viral vaccines and alum precipitated toxoids have been effectively and routinely used in immunization injections for many years. The explanation usually given for the effect of such preparations is that the physical chemical absorption of an antigen onto an alum complex results in a slower release of the antigen with a consequent prolongation of the antigenic stimulus.

The treatment consists of the subcutaneous injection of gradually increasing doses of the allergens to which the patient is allergic. It has been demonstrated that this method of treatment induces an increased tolerance to the allergens responsible for the symptoms on subsequent exposure. Although the exact relationships between allergen, skin-sensitizing antibody (IgE) and the blocking antibody (IgG) have not been precisely established, clinically confirmed immunological studies have demonstrated the safety of Center-Al extracts and effectiveness in terms of symptom reduction and IgG response consistent with dose administered.³

In a controlled study with Center-Al Ragweed given pre-seasonally, patients were selected and matched by histamine release to Antigen E and assigned to treatment groups: Aqueous, Center-Al, and Placebo^3. All patients were highly sensitive to Ragweed Antigen E, reacting to <0.001 mcg Antigen E/mL as determined by intradermal skin testing. These patients received a pre-seasonal course of immunotherapy and achieved a mean cumulative dose of 52 units of Antigen E (27,365 PNU) in 13 to 19 injections. Starting doses in these patients were 10 PNU or approximately 0.02 units of AgE. This dosage was found to be significantly superior to Placebo as measured by symptom scores during the ragweed pollen season.

Although maximum tolerated doses for Center-Al expressed in AgE content has not specifically been studied, one investigator reported maximum tolerated doses with Center-Al ragweed at 2,000-5,000 PNU (4-10 units of Antigen E) with previously untreated patients.⁹ At least three investigators using mixed (tall and short) ragweed extracts demonstrated a maximum tolerated peak dose of 2,000 to 10,000 PNU in 10-13 injections in moderately sensitive patients.^6,10-12 This was achieved by roughly doubling the dose in each successive injection at low dosages (<1,000 PNU) and if well tolerated, increasing the dosage approximately 50% until maximum tolerated dose for each patient was achieved.

Reaction rates for these patients were significantly lower than patients treated with aqueous extracts with the same or more conservative dosage regimen.^3,7,8,11

     

Hyposensitization (injection) therapy is a treatment for patients exhibiting allergic reactions to seasonal pollens, dust mites, molds, animal danders, and various other inhalants, in situations where the offending allergen cannot be avoided.

Prior to the initiation of therapy, clinical sensitivity should be established by careful evaluation of the patient's history confirmed by diagnostic skin testing. Hyposensitization should not be prescribed for sensitivities to allergens which can be easily avoided.

A patient should not be immunized against a substance which the patient has not demonstrated symptoms and/or tissue-fixed IgE antibodies as demonstrated by skin testing. Immunotherapy should not be attempted in patients with active asthma, severe respiratory obstruction, or cardiovascular disease.

There is some evidence, although inconclusive, that routine immunizations may exacerbate autoimmune diseases. Hyposensitization should be given cautiously to patients with this predisposition. The physician must weigh risk to benefit in these rare cases.

Patients with Alzheimer's disease, Down's syndrome and renal insufficiency are theoretically at risk from aluminum intake, including alum precipitated allergenic extracts.

     

Patients should always be observed for at least 20-30 minutes after any injection. In the event of a marked systemic reaction, application of a tourniquet above the injection site and administration of 0.2 mL to 1.0 mL of Epinephrine injection (1:1,000) are recommended. Maximal recommended dose for children under 2 years of age is 0.3 mL. Maximal recommended dose for children between 2 and 12 years of age is 0.5 mL. The tourniquet is then gradually released. Patients under treatment with beta-blockers may be refractory to the usual dose of epinephrine.

Information For Patients: Patients should be instructed to describe any active allergic symptoms such as rhinitis, wheezing, dyspnea, etc. prior to injection including any late reactions from previous administration. Patients should be instructed to remain in the office for 20 to 30 minutes after injection to monitor for adverse reactions. Also, see ADVERSE REACTIONS and WARNINGS  sections.

General:

• Center-Al Allergenic Extracts, Alum Precipitated, are not to be used for intradermal testing.
  
• Store at temperatures 2° - 8°C at all times, even during use.
  
• DO NOT FREEZE. Freezing may cause agglomeration.
  
• Shake vial thoroughly to disperse suspension prior to removal of the dose to be administered.
  
• A separate sterile syringe and needle should be used for each individual patient, to prevent transmission of homologous serum hepatitis and other infectious agents from one person to another.
  
• Injections are to be administered subcutaneously with the usual sterile precautions, preferably in the upper outer aspects of the arm, using a sterile tuberculin-type syringe and 25 or 26 gauge needle,½ to ¼ in length.
  
• Avoid injecting intravenously. Pull back gently on syringe plunger and note if blood enters the syringe. If blood should enter the syringe, withdraw the needle and reinsert at another site, repeating the same precaution.
  
• Allergenic extracts slowly become less potent with age. During the course of treatment, it may be necessary to continue therapy with a vial of extract bearing a later expiration date. The initial dose of the extract bearing the later expiration date should be lowered to a safe non-reaction-eliciting level, usually reducing the dosage of the first injection of the new vial 50-75% of the previous well tolerated dose of the older vial.
  
• Subcutaneous nodules may develop at injection sites. The incidence of nodules increases with higher dosage of individual products and with extemporaneous mixtures at lower dosage. No single dose should provide more than 5,000 PNU whether as single allergen or mixture nor should it exceed 0.5 mL in volume. If nodules occur, the highest single dose administered should be limited to a maximum of 0.2 mL (2,000 PNU).

Center-Al Allergenic Extracts, Alum Precipitated, are not to be mixed with any non-alum containing allergen(s) or with other types of alum precipitated products. Such mixing may free the alum-absorbed allergens.

Center-Al Allergenic Extracts, Alum Precipitated, should be diluted only with Sterile Diluent for Allergenic Extracts (Phenol-Saline) containing 0.9% Sodium Chloride, 0.4% Phenol. Use of other types of diluents may result in re-solution of some of the alum-complexed allergen thereby resulting in release of free aqueous extracts.

Patients receiving beta-blockers may not be responsive to epinephrine or an inhaled bronchodilator.

Animal reproduction studies have not been conducted with Center-Al (Allergenic Extracts, Alum Precipitated). It is also not known whether Center-Al can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.

Controlled studies of hyposensitization with moderate to high doses of allergenic extracts during conception and all trimesters of pregnancy have failed to demonstrate any risk to the fetus or to the mother. However, on the basis of histamine's known ability to contract the uterine muscle, the release of significant amounts of histamine from allergen exposure or hyposensitization overdose should be avoided on theoretical grounds. Therefore, allergenic extracts should be used cautiously in a pregnant woman and only if clearly needed.

Children can receive the same dose as adults, however, to minimize discomfort associated with dose volume it may be advisable to reduce the volume of the dose by one-half and administer the injection at two different sites.

It is not known if allergens administered subcutaneously appear in human milk. Because many drugs are excreted in human milk, caution should be exercised when allergenic extracts are administered to a nursing woman.

Studies in animals have not been performed.

     

Local: Reactions at the site of injection may be immediate or delayed. Immediate wheal and erythema reactions are ordinarily of little consequence, but if very large may be the first manifestation of a systemic reaction. If large local reactions occur, the patient should be observed for systemic symptoms for which treatment is outlined below.

Delayed reactions start several hours after injection with local edema, erythema, itching or pain. They are usually at their peak at 24 hours and usually require no treatment. Antihistamine drugs may be administered orally.

The next therapeutic dose should be reduced to the dose which did not elicit a reaction, and subsequent doses increased more slowly, i.e., use of intermediate dilutions.

Systemic: It should be noted that anaphylaxis and deaths following the injection of mite and other extracts, including pollen extracts, have been reported by The British Committee on Safety in Medicine.¹³ Fatalities from immunotherapy in the United States since 1945 have been extensively reviewed by Lockey, R.F., et al.¹⁴ and also more recently by Reid, M.J., et al.¹⁵ With careful attention to dosage and administration, such reactions occur infrequently, but it must be remembered that allergenic extracts are highly potent to sensitive individuals and OVERDOSE could result in anaphylactic symptoms. Therefore, it is imperative that physicians administering allergenic extracts understand and be prepared for the treatment of severe reactions.

Systemic reactions are characterized by one or more of the following symptoms: sneezing, mild to severe generalized urticaria, itching other than at the injection site, extensive or generalized edema, wheezing, asthma, dyspnea, cyanosis, tachycardia, lacrimation, marked perspiration, cough, hypotension, syncope and upper airway obstruction. Symptoms may progress to shock and death. Patients should always be observed for at least 20-30 minutes after any injection.

Volume expanders and vasopressor agents may be required to reverse hypotension. Inhalational bronchodilator and parenteral aminophylline may be required to reverse bronchospasm. Severe airway obstruction, unresponsive to bronchodilator, may require tracheal intubation.

In the event of a marked systemic reaction, application of a tourniquet above the injection site and administration of 0.2 mL to 1.0 mL of Epinephrine Injection (1:1,000) are recommended. Maximal recommended dose for children under 2 years of age is 0.3 mL. Maximal recommended dose for children between 2 and 12 years of age is 0.5 mL. The tourniquet is then gradually released.

The next therapeutic injection of extract should be reduced to the dose which did not elicit a reaction, and subsequent doses increased more slowly, i.e., use of intermediate dilutions.

Adverse Events should be reported via MedWatch (1-800-FDA-1088), Adverse Experience Reporting, HFM-210 Center for Biologics Evaluation & Research, Food & Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448.

     

The starting dose for immunotherapy is related directly to a patient's sensitivity as determined by carefully executed percutaneous (prick/puncture) and intracutaneous (intradermal) skin testing with non-alum adsorbed allergenic extract. A general rule is to begin at 1/10 of the intradermal dose that produces sum of erythema of 50 mm (approximately a 2+ positive skin test reaction). Patient's response to skin testing is graded on the basis of the size of the erythema and wheal. Refer to the diagnostic allergenic extract package enclosure for specific information.

TRANSFER OF PATIENTS FROM OTHER

AQUEOUS EXTRACTS TO

CENTER-AL EXTRACTS

Patients may be transferred from other aqueous allergens to Center-Al Alum Precipitated Extracts during treatment. To avoid untoward reactions, it may be necessary to initiate treatment as though the patient were previously untreated. In transferring from standardized extracts, the more rapid rate of decline in activity of aqueous extract relative to alum precipitated extract must be considered in cautiously transferring patients to alum precipitated extract.

Caution should be observed since the Center-Al preparation may be more potent than the aqueous product.

TRANSFER OF PATIENTS FROM OTHER

ALUM-COMPLEXED EXTRACTS TO

CENTER-AL EXTRACTS

Patients may be transferred from other alum-complexed allergenic extracts to Center-Al Alum Precipitated extracts. In order to avoid untoward reactions, it is recommended that previous therapy be disregarded and therapy with Center-Al be initiated as though the patient were previously untreated. The first dose of Center-Al should be related to the patient's sensitivity, determined by history and confirmed by skin testing. CAUTION: Center-Al Alum Precipitated extracts should not be mixed with other alum precipitated or aqueous extracts.

PRE-SEASONAL AND PERENNIAL METHOD OF TREATMENT

The use of Center-Al Allergenic extract, Alum Precipitated, in the treatment of patients by the pre-seasonal method should be started 10 to 12 weeks prior to the usual onset of symptoms. Therapy should be initiated early enough to permit a graduated series of doses at weekly intervals. It is recommended that the larger doses be spaced 2 to 3 weeks apart and that the top dose be reached prior to the season.

Increased tolerance acquired through hyposensitization can vary from a few to several months. To assure prolongation of this acquired tolerance, perennial or year-round treatment is recommended.

Some physicians continue therapy into or through the season by repeating a reduced MAINTENANCE dose at 4 to 6 week intervals.

SUGGESTED DOSAGE SCHEDULE

A treatment schedule is related directly to the patient's degree of sensitivity, determined initially by clinical history and skin testing, and continuously by response to therapeutic doses. Thus, an individual treatment schedule for each patient must be established during the course of therapy. Maximum protection can be obtained with a dosage kept constantly below the patient's limit of tolerance. Every precaution should be taken to avoid a systemic or generalized reaction which in addition to being dangerous, may depress rather than increase the patient's tolerance.

FOR ALL PREPARATIONS (EXCEPT SHORT RAGWEED

AND MIXED SHORT AND TALL RAGWEED)

Labeled Antigen E content of extracts containing Short Ragweed at a weight/volume concentration more dilute than 1:10 may have been obtained by calculation from the Antigen E assay value of a more concentrated extract that was analyzed, officially released by the Office of Biologics, and subsequently diluted.

Below is listed a suggested dosage schedule for Pre-Seasonal Treatment. A column has been left blank for AgE dosage of short ragweed containing extracts.

Note: For extracts of short ragweed or equal part mixture of Short and Tall Ragweed refer to AgE dosage schedule. The AgE content for those products is indicated on the vial label. The physician may use the formula below to determine the AgE dosage for each injection.

      AgE dosage can be monitored by using the formula:

Note: Suggested dosage schedules which follow have not been subjected to adequate and well controlled trials to establish their safety and efficacy.

Dose No.	Vial Strength	Volume Injected	PNU Per Dose	AgE Dose
1	100 PNU/mL	0.1 mL	10
2	100 PNU/mL	0.2 mL	20
3	100 PNU/mL	0.5 mL	50
4	1,000 PNU/mL	0.1 mL	100
5	1,000 PNU/mL	0.25 mL	250
6	1,000 PNU/mL	0.5 mL	500
7	10,000 PNU/mL	0.1 mL	1,000
8	10,000 PNU/mL	0.2 mL	2,000
9	10,000 PNU/mL	0.3 mL	3,000
10	10,000 PNU/mL	0.4 mL	4,000
11	10,000 PNU/mL	0.5 mL	5,000
MAINTENANCE DOSE:
	10,000 PNU/mL	0.5 mL	5,000

NO SINGLE DOSE SHOULD EXCEED 5,000 PNU. For continuing therapy with extracts containing Short Ragweed, see following section on Dosage Adjustments.

SHORT RAGWEED EQUAL PARTS

MIXES OF SHORT AND TALL RAGWEED

(DOSAGE BASED ON ANTIGEN CONTENT)

Suggested dosage schedule for Short Ragweed and Equal Part Mixture of Short and Tall Ragweed:

Dose No	AgE Units/mL	Volume   Injected	AgE Per Dose
1	0.4	0.1	0.04
2	0.4	0.2	0.08
3	0.4	0.5	0.2
4	4	0.1	0.4
5	4	0.25	1
6	4	0.5	2
7	40	0.1	4
8	40	0.2	8
9	40	0.3	12
10	40	0.4	16
11	40	0.5	20
MAINTENANCE DOSE:
	40	0.5	20
	80	0.25	20

NO SINGLE DOSE SHOULD EXCEED 20 UNITS

DOSAGE ADJUSTMENTS

(FOR PRODUCTS CONTAINING SHORT RAGWEED)

AgE is important in adjusting dosage of Short Ragweed extracts to accurately transfer a patient from older extracts to fresher material. In such cases, the dosage of AgE should be considered in addition to the protein nitrogen units. Antigen E concentration continuously declines in Short Ragweed Pollen extracts at a rate that varies with the formulation of the product. Aqueous extracts retain Antigen E potency less effectively than 50% glycinerated or Alum Precipitated extracts. Antigen E is most stable in freeze-dried extracts. These differences are reflected in the expiration date declared on the vial label. The continuous decline should be considered. Also, where Ragweed is a component of an allergen mixture, clinical response to the other components must be considered in adjustment of dosage based on AgE content alone.

CAUTION: A small percent of individuals allergic to Short Ragweed are more sensitive to minor antigens such as Ra3 and Ra5 than AgE. There is no correlation between the amount of these antigens and either AgE or PNU content.

Therapeutic Center-Al Allergenic Extracts, Alum Precipitated, are supplied in 10 mL and 30 mL vials, in concentrations of 10,000 PNU/mL and 20,000 PNU/mL. Prescription treatment sets for individual patients are also available. Center-Al must be stored continuously at 2° to 8°C. DO NOT FREEZE. Diluent: Sterile Diluent for allergenic extracts (Phenol-Saline) is provided in vials of 4.5 mL, 9.0 mL, and 30 mL.

STORAGE: To maintain stability of allergenic extracts, proper storage conditions are essential. Bulk concentrates and diluted extracts are to be stored at 2° to 8°C even during use. Bulk or diluted extracts are not to be frozen. Do not use after the expiration date shown on the vial label.

• Norman, P.S. et. al.: Immunotherapy of hayfever with ragweed antigen E. Comparisons with whole pollen extract and placebo. J. Allergy 42:93, 1968.
  
• Van Metre, T.E. et. al.: A controlled study of the effectiveness of the Rinkel method of immunotherapy for ragweed pollen hayfever. J. Allergy Clin. Immunol. 61:384, 1978.
  
• Norman, P.S. and Lichtenstein, L.M.: Comparisons of alum precipitated and unprecipitated aqueous ragweed pollen extracts in the treatment of hayfever. J. Allergy Clin. Immunol. 61:384, 1978.
  
• Ransom, J.H.: Clinical and laboratory evaluation of alum precipitated ragweed extract. Ann. Allergy 28:22, 1970.
  
• Ransom, J.H.: Frequency of reactions to alum precipitated ragweed extract. Ann. Allergy 29:635, 1971.
  
• Lazar, H. and Leoffler, J.A.: Evaluation of an alum precipitated mixed ragweed antigen: a three-year study. Ann. Allergy 28:214, 1970.
  
• Norman, P.S. Winkenwerder, W.L., and Lichtenstein, L.M.: Trials of alum precipitated pollen extracts in the treatment of hayfever. J. Allergy Clin. Immunol. 50:31, 1972.
  
• Nelson, H.S.: Long-term immunotherapy with aqueous and alum precipitated grass extracts. Ann. Allergy 45:333, 1980.
  
• Norman, P.S.: The role of In-Vitro assays in the evaluation of immunotherapy. Recent Advances in Immunotherapy. Port Washington, NY 1973.
  
• Lazar, H.: Clinical presentation covering 6 years of observation. Recent Advances in Immunotherapy. Port Washington, NY 1973.
  
• Haynes, J.T.: A clinical study of 23 ragweed sensitive patients. Recent Advances in Immunotherapy. Port Washington, NY 1973.
  
• Ransom, J.H.: Ragweed patient study. Recent Advances in Immunotherapy. Port Washington, NY 1973.
  
• Committee on the Safety of Medicines. CSM update: desensitizing vaccines. Brit. Med. J. 1986; 293:948.
  
• Lockey, R.F. et al.: Fatalities from immunotherapy (IT) and skin testing (ST). J. Allergy Clin. Immunol. 1987; 79:660.
  
• Reid, M.J. et al.: Survey of fatalities from skin testing and immunotherapy. 1985-1989. J. Allergy Clin Immunol. 1993; 92:6.

Distributed in Canada by:
Western Allergy Services, LTD.
121-6154 Westminister Highway
Richmond, B.C. V7C404

Revision: June 2002
© ALK-Abelló, Inc. 2002                                                 168F

CENTER-AL - ACACIA LONGIFOLIA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0021 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ACACIA LONGIFOLIA POLLEN Acacia longifolia pollen 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0021-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ALNUS INCANA SSP. RUGOSA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0024 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ALNUS INCANA SSP. RUGOSA POLLEN ALNUS INCANA SSP. RUGOSA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0024-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0024-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - FRAXINUS AMERICANA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0027 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength FRAXINUS AMERICANA POLLEN FRAXINUS AMERICANA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0027-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0027-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PASPALUM NOTATUM POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0030 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PASPALUM NOTATUM POLLEN PASPALUM NOTATUM POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0030-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0030-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PASPALUM NOTATUM POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0031 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PASPALUM NOTATUM POLLEN PASPALUM NOTATUM POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0031-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - FAGUS GRANDIFOLIA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0034 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength FAGUS GRANDIFOLIA POLLEN FAGUS GRANDIFOLIA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0034-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - CYNODON DACTYLON POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0038 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CYNODON DACTYLON POLLEN CYNODON DACTYLON POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0038-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - CYNODON DACTYLON POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0037 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CYNODON DACTYLON POLLEN CYNODON DACTYLON POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0037-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0037-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - BETULA LENTA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0041 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength BETULA LENTA POLLEN BETULA LENTA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0041-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0041-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ACER NEGUNDO POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0047 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ACER NEGUNDO POLLEN ACER NEGUNDO POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0047-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0047-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - BROMUS INERMIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0050 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength BROMUS INERMIS POLLEN BROMUS INERMIS POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0050-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - XANTHIUM STRUMARIUM POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0054 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength XANTHIUM STRUMARIUM POLLEN XANTHIUM STRUMARIUM POLLEN 5000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0054-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - XANTHIUM STRUMARIUM POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0053 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength XANTHIUM STRUMARIUM POLLEN XANTHIUM STRUMARIUM POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0053-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0053-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ZEA MAYS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0057 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ZEA MAYS POLLEN ZEA MAYS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0057-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - POA ANNUA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0044 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength POA ANNUA POLLEN POA ANNUA POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0044-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - POPULUS DELTOIDES SSP. MONILIFERA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0060 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength POPULUS DELTOIDES SSP. MONILIFERA POLLEN POPULUS DELTOIDES SSP. MONILIFERA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0060-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0060-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - RUMEX ACETOSELLA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0063 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength RUMEX ACETOSELLA POLLEN RUMEX ACETOSELLA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0063-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0063-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - RUMEX CRISPUS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0066 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength RUMEX CRISPUS POLLEN RUMEX CRISPUS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0066-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0066-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ULMUS AMERICANA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0069 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ULMUS AMERICANA POLLEN ULMUS AMERICANA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0069-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0069-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ULMUS PUMILA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0072 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ULMUS PUMILA POLLEN ULMUS PUMILA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0072-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0072-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - CORYLUS AMERICANA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0075 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CORYLUS AMERICANA POLLEN CORYLUS AMERICANA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0075-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - CARYA OVATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0078 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CARYA OVATA POLLEN CARYA OVATA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0078-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0078-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - HOUSE DUST Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0081 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength HOUSE DUST HOUSE DUST 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0081-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0081-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - HOUSE DUST Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0082 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength HOUSE DUST HOUSE DUST 1000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0082-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - HOUSE DUST Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0083 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength HOUSE DUST HOUSE DUST 10 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0083-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - HOUSE DUST Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0084 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength HOUSE DUST HOUSE DUST 100 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0084-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - SORGHUM HALEPENSE POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0087 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength SORGHUM HALEPENSE POLLEN SORGHUM HALEPENSE POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0087-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0087-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - POA PRATENSIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0090 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength POA PRATENSIS POLLEN POA PRATENSIS POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0090-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0090-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - POA PRATENSIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0091 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength POA PRATENSIS POLLEN POA PRATENSIS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0091-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - KOCHIA SCOPARIA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0094 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength KOCHIA SCOPARIA POLLEN KOCHIA SCOPARIA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0094-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0094-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - CHENOPODIUM ALBUM POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0097 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CHENOPODIUM ALBUM POLLEN CHENOPODIUM ALBUM POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0097-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0097-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ACER SACCHARUM POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0100 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ACER SACCHARUM POLLEN ACER SACCHARUM POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0100-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0100-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - FESTUCA PRATENSIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0103 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength FESTUCA PRATENSIS POLLEN FESTUCA PRATENSIS POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0103-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - FESTUCA PRATENSIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0104 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength FESTUCA PRATENSIS POLLEN FESTUCA PRATENSIS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0104-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PROSOPIS JULIFLORA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0107 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PROSOPIS JULIFLORA POLLEN PROSOPIS JULIFLORA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0107-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0107-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ARTEMISIA VULGARIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0110 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ARTEMISIA VULGARIS POLLEN ARTEMISIA VULGARIS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0110-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0110-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - MORUS RUBRA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0113 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength MORUS RUBRA POLLEN MORUS RUBRA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0113-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0113-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - QUERCUS AGRIFOLIA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0116 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength QUERCUS AGRIFOLIA POLLEN QUERCUS AGRIFOLIA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0116-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0116-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - QUERCUS VIRGINIANA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0119 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength QUERCUS VIRGINIANA POLLEN QUERCUS VIRGINIANA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0119-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - QUERCUS ALBA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0122 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength QUERCUS ALBA POLLEN QUERCUS ALBA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0122-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0122-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AVENA SATIVA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0125 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AVENA SATIVA POLLEN AVENA SATIVA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0125-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - OLEA EUROPAEA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0128 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength OLEA EUROPAEA POLLEN OLEA EUROPAEA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0128-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0128-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - OLEA EUROPAEA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0129 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength OLEA EUROPAEA POLLEN OLEA EUROPAEA POLLEN 1000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0129-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - OLEA EUROPAEA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0130 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength OLEA EUROPAEA POLLEN OLEA EUROPAEA POLLEN 10 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0130-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - OLEA EUROPAEA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0131 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength OLEA EUROPAEA POLLEN OLEA EUROPAEA POLLEN 100 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0131-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - DACTYLIS GLOMERATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0134 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength DACTYLIS GLOMERATA POLLEN DACTYLIS GLOMERATA POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0134-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - CARYA ILLINOINENSIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0137 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CARYA ILLINOINENSIS POLLEN CARYA ILLINOINENSIS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0137-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0137-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMARANTHUS RETROFLEXUS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0140 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMARANTHUS RETROFLEXUS POLLEN AMARANTHUS RETROFLEXUS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0140-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0140-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMARANTHUS RETROFLEXUS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0141 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMARANTHUS RETROFLEXUS POLLEN AMARANTHUS RETROFLEXUS POLLEN 5000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0141-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PLANTAGO LANCEOLATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0144 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PLANTAGO LANCEOLATA POLLEN PLANTAGO LANCEOLATA POLLEN 1000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0144-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PLANTAGO LANCEOLATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0146 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PLANTAGO LANCEOLATA POLLEN PLANTAGO LANCEOLATA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0146-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0146-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PLANTAGO LANCEOLATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0145 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PLANTAGO LANCEOLATA POLLEN PLANTAGO LANCEOLATA POLLEN 100 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0145-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PLANTAGO LANCEOLATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0147 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PLANTAGO LANCEOLATA POLLEN PLANTAGO LANCEOLATA POLLEN 10 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0147-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - POPULUS ALBA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0150 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength POPULUS ALBA POLLEN POPULUS ALBA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0150-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0150-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMBROSIA ACANTHICARPA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0153 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMBROSIA ACANTHICARPA POLLEN AMBROSIA ACANTHICARPA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0153-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMBROSIA ACANTHICARPA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0156 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMBROSIA ARTEMISIIFOLIA POLLEN AMBROSIA ARTEMISIIFOLIA POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0156-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMBROSIA ACANTHICARPA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0157 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMBROSIA ARTEMISIIFOLIA POLLEN AMBROSIA ARTEMISIIFOLIA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0157-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMBROSIA TRIFIDA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0160 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMBROSIA TRIFIDA POLLEN AMBROSIA TRIFIDA POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0160-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMBROSIA TRIFIDA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0161 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMBROSIA TRIFIDA POLLEN AMBROSIA TRIFIDA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0161-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AMBROSIA PSILOSTACHYA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0164 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AMBROSIA PSILOSTACHYA POLLEN AMBROSIA PSILOSTACHYA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0164-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0164-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - AGROSTIS GIGANTEA Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0167 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength AGROSTIS GIGANTEA AGROSTIS GIGANTEA 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0167-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0167-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - SALSOLA KALI POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0170 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength SALSOLA KALI POLLEN SALSOLA KALI POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0170-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0170-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - LOLIUM PERENNE POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0173 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength LOLIUM PERENNE POLLEN LOLIUM PERENNE POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0173-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0173-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - LOLIUM PERENNE POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0174 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength LOLIUM PERENNE POLLEN LOLIUM PERENNE POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0174-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0174-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ARTEMISIA TRIDENTATA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0177 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ARTEMISIA TRIDENTATA POLLEN ARTEMISIA TRIDENTATA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0177-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0177-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ATRIPLEX WRIGHTII POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0180 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ATRIPLEX WRIGHTII POLLEN ATRIPLEX WRIGHTII POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0180-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - ATRIPLEX WRIGHTII POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0183 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ATRIPLEX WRIGHTII POLLEN ATRIPLEX WRIGHTII POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0183-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PLATANUS OCCIDENTALIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0186 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PLATANUS OCCIDENTALIS POLLEN PLATANUS OCCIDENTALIS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0186-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0186-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PLATANUS RACEMOSA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0189 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PLATANUS RACEMOSA POLLEN PLATANUS RACEMOSA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0189-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0189-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PHLEUM PRATENSE POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0192 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PHLEUM PRATENSE POLLEN PHLEUM PRATENSE POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0192-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0192-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - PHLEUM PRATENSE POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0193 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength PHLEUM PRATENSE POLLEN PHLEUM PRATENSE POLLEN 20000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0193-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0193-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - HOLCUS LANATUS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0196 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength HOLCUS LANATUS POLLEN HOLCUS LANATUS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0196-10 10 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - JUGLANS NIGRA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0199 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength JUGLANS NIGRA POLLEN JUGLANS NIGRA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0199-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0199-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - JUGLANS CALIFORNICA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0202 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength JUGLANS CALIFORNICA POLLEN JUGLANS CALIFORNICA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0202-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - SALIX NIGRA POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-0205 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength SALIX NIGRA POLLEN SALIX NIGRA POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-0205-10 10 in 1 VIAL, MULTI-DOSE 2 NDC:0268-0205-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15

CENTER-AL - BROMUS INERMIS POLLEN Allergenic Extracts Alum Precipitated INJECTION, SUSPENSION Product Information Product Type Human prescription drug label Item Code (Source) NDC:0268-1088 Route of Administration SUBCUTANEOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength BROMUS INERMIS POLLEN BROMUS INERMIS POLLEN 10000 [PNU] Inactive Ingredients Ingredient Name Strength ALUM, POTASSIUM SODIUM HYDROXIDE PHENOL SODIUM CHLORIDE HYDROCHLORIC ACID SODIUM HYDROXIDE Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0268-1088-30 30 in 1 VIAL, MULTI-DOSE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date BLA BLA103753 1975-01-15