In-111 DTPA description, usages, side effects, indications, overdosage, supplying and lots more!

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In-111 DTPA

AnazaoHealth Corporation

In-111 DTPA (In-111 Pentetate Disodium)




FULL PRESCRIBING INFORMATION

In-111 DTPA is supplied as a sterile, pyrogen-free, isotonic, aqueous solution that is  buffered to pH 7 to 8. At calibration time, each milliliter contains 2.5 mCi of Pentetate Indium Disodium In-111 (no carrier-added) and sodium bicarbonate for pH adjustment.

Indium 111 decays by electron capture with a physical half-life of 67.9 hour. The energies of the photons that are useful for detection and imaging studies are:

Radiation Mean % Disintegration Mean Energy (keV)

Gamma-2 90.2 171.3

Gamma-3 94.0 245.4

In-111 DTPA is indicated for use in  radionuclide cisternography

After intrathecal administration, the In-111 DTPA is absorbed from the subarachnoid space and the remainder flows superiorly to the basal cisterns within 2 to 4 hours and subsequently will be apparent in the Sylvian cisterns, the interhemispheric cisterns, and over the cerebral convexities. In normal individuals, the it  will have ascended to the parasagittal region within 24 hours with simultaneous partial or complete clearance of activity from the basal cisterns and Sylvian regions. In contrast to air, In-111 DTPA does not normally enter the cerebral ventricles

There are no known contraindications

Extreme care must be exercised to assure aseptic conditions in intrathecal injections. The maximum recommended intrathecal dose in the average patient (70kg) is 18.5 megabecquerels (500 microcuries). The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration. Parenteral drug preparations should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Store vial in its lead shield at a temperature of 5-30º C. Do not freeze

Figure 1

In-111 DTPA

In-111 DTPA

In-111 DTPA SOLUTION

Product Information

Product Type Human prescription drug label Item Code (Source) NDC:51808-125
Route of Administration INTRATHECAL DEA Schedule

Active Ingredient/Active Moiety

Ingredient Name Basis of Strength Strength
Indium IN-111 Pentetate Disodium PENTETIC ACID 3.75 mCi

Inactive Ingredients

Ingredient Name Strength
SODIUM BICARBONATE

Packaging

# Item Code Package Description Marketing Start Date Marketing End Date
1 NDC:51808-125-01 1.5 in 1 VIAL

Marketing Information

Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
2012-06-19


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