Topical Cleanser

Harris Pharmaceutical, Inc.
Groupe PARIMA, Inc.

BENZOYL PEROXIDE TOPICAL CLEANSER 6%

FULL PRESCRIBING INFORMATION

Rx Only

DESCRIPTION:
Benzoyl Peroxide Topical Cleanser 6% is a topical, gel-based, benzoyl peroxide containing preparation for use in the treatment of acne vulgaris. Benzoyl peroxide is an oxidizing agent that possesses antibacterial properties and is classified as a keratolytic. Benzoyl peroxide (C₁₄H₁₀O₄) is represented by the following chemical structure:

Benzoyl Peroxide Topical Cleanser 6% contains Benzoyl Peroxide USP 6% as the active ingredient, in a vehicle consisting of: carbomer interpolymer type A NF, cetyl alcohol NF, disodium oleamido MEA-sulfosuccinate, edetate disodium USP, glycerin USP, glyceryl stearate/PEG-100 stearate, laureth-12, magnesium aluminum silicate NF, propylene glycol USP, purified water, sodium coco-sulfate, sodium lauroamphoacetate, xanthan gum NF.

CLINICAL PHARMACOLOGY:
The mechanism of action of benzoyl peroxide is not totally understood but its antibacterial activity against Propionibacterium acnes is thought to be a major mode of action. In addition, patients treated with benzoyl peroxide show a reduction in lipids and free fatty acids, and mild desquamation (drying and peeling activity) with simultaneous reduction in comedones and acne lesions. Little is known about the percutaneous penetration, metabolism, and excretion of benzoyl peroxide, although it has been shown that benzoyl peroxide absorbed by the skin is metabolized to benzoic acid and then excreted as benzoate in the urine. There is no evidence of systemic toxicity caused by benzoyl peroxide in humans.

Uses

INDICATIONS AND USAGE:
Benzoyl Peroxide Topical Cleanser 6% is indicated for the topical treatment of acne vulgaris.

CONTRAINDICATIONS:
This preparation is contraindicated in patients with a history of hypersensitivity to any of its components.

WARNINGS:
When using this product, avoid unnecessary sun exposure and use a sunscreen.

PRECAUTIONS:
General:
For external use only. If severe irritation develops, discontinue use and institute appropriate therapy. After reaction clears, treatment may often be resumed with less frequent application. These preparations should not be used in or near the eyes or on mucous membranes.

Information for Patients:
Avoid contact with eyes, eyelids, lips and mucous membranes. If accidental contact occurs, rinse with water. Contact with any colored material (including hair and fabric) may result in bleaching or discoloration. If excessive irritation develops, discontinue use and consult your physician.

Carcinogenesis, Mutagenesis, Impairment of Fertility:
Data from several studies employing a strain of mice that are highly susceptible to developing cancer suggest that benzoyl peroxide acts as a tumor promoter. The clinical significance of these findings to humans is unknown. Benzoyl peroxide has not been found to be mutagenic (Ames Test) and there are no published data indicating it impairs fertility.

Pregnancy:
Teratogenic Effects:
Pregnancy Category C: Animal reproduction studies have not been conducted with benzoyl peroxide. It is not known whether benzoyl peroxide can cause fetal harm when administered to a pregnant woman or can effect reproduction capacity. Benzoyl peroxide should be used by a pregnant woman only if clearly needed. There are no available data on the effect of benzoyl peroxide on the later growth, development and functional maturation of the unborn child.

Nursing Mothers:
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be
exercised when benzoyl peroxide is administered to a nursing woman.

Pediatric Use:
Safety and effectiveness in children have not been established.

ADVERSE REACTIONS:
Allergic contact dermatitis and dryness have been reported with topical benzoyl peroxide therapy.

HOW SUPPLIED:
Benzoyl Peroxide Topical Cleanser 6% – 6 oz.(170.3 g) bottle, NDC 67405-435-06

Benzoyl Peroxide Topical Cleanser6% – 12oz.(340.2g) bottle, NDC 67405-435-12

Store at 15°–25°C(59°–77°F).

Manufactured for:
HARRIS Pharmaceutical, Inc.
Ft. Myers, FL
33908
877-RX4-DERM
www.HarrisPharmaceutical.com

Manufactured by:
Groupe Parima
Montreal,QC H4S 1X6
CANADA