Verapamil Hydrochloride
FULL PRESCRIBING INFORMATION: CONTENTS*
- VERAPAMIL HYDROCHLORIDE DESCRIPTION
- CLINICAL PHARMACOLOGY
- INDICATIONS & USAGE
- VERAPAMIL HYDROCHLORIDE CONTRAINDICATIONS
- WARNINGS
- PRECAUTIONS
- DRUG INTERACTIONS
- CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY
- PREGNANCY
- LABOR & DELIVERY
- NURSING MOTHERS
- PEDIATRIC USE
- ANIMAL PHARMACOLOGY & OR TOXICOLOGY
- VERAPAMIL HYDROCHLORIDE ADVERSE REACTIONS
- OVERDOSAGE
- DOSAGE & ADMINISTRATION
- HOW SUPPLIED
- STORAGE AND HANDLING
- PACKAGE LABEL.PRINCIPAL DISPLAY PANEL SECTION
FULL PRESCRIBING INFORMATION
VERAPAMIL HYDROCHLORIDE DESCRIPTION
CLINICAL PHARMACOLOGY
Mechanism of action
Arrhythmia:
WARNINGS
WARNINGS
Pharmacokinetics and metabolism
PRECAUTIONS
After four weeks of oral dosing (120 mg q.i.d.), verapamil and norverapamil levels were noted in the cerebrospinal fluid with estimated partition coefficient of 0.06 for verapamil and 0.04 for norverapamil.
Hemodynamics and myocardial metabolism
Verapamil reduces afterload and myocardial contractility. Improved left ventricular diastolic function in patients with IHSS and those with coronary heart disease has also been observed with verapamil hydrochloride therapy. In most patients, including those with organic cardiac disease, the negative inotropic action of verapamil is countered by reduction of afterload, and cardiac index is usually not reduced. However, in patients with severe left ventricular dysfunction (e.g., pulmonary wedge pressure above 20 mm Hg or ejection fraction less than 30%), or in patients taking beta-adrenergic blocking agents or other cardiodepressant drugs, deterioration of ventricular function may occur (seeDrug interactions).
Pulmonary function
Verapamil does not induce bronchoconstriction and, hence, does not impair ventilatory function.
INDICATIONS & USAGE
Angina
Arrhythmias
WARNINGSAccessory Bypass Tract)
2. Prophylaxis of repetitive paroxysmal supraventricular tachycardia
Essential Hypertension
VERAPAMIL HYDROCHLORIDE CONTRAINDICATIONS
WARNINGS
WARNINGS
WARNINGS
Heart failure
Drug interactions
Hypotension
Elevated liver enzymes
Accessory bypass tract (Wolff-Parkinson-White or Lown-Ganong-Levine)
CONTRAINDICATIONS
Atrioventricular block
Patients with hypertrophic cardiomyopathy (IHSS)
Drug interactions
PRECAUTIONS
GeneralUse in patients with impaired hepatic function:OVERDOSAGE
Use in patients with attenuated (decreased) neuromuscular transmission:
Use in patients with impaired renal function:OVERDOSAGE
DRUG INTERACTIONS
Alcohol:Beta-blockers:
Digitalis:
Antihypertensive agents:
Antiarrhythmic agents:
Disopyramide:
Flecainide:
Quinidine:
Other:
Nitrates:
Cimetidine:
Lithium:
Carbamazepine:
Rifampin:
Phenobarbital:
Cyclosporin:
Theophylline:
Inhalation anesthetics:
Neuromuscular blocking agents:
CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY
PREGNANCY
Teratogenic effects:LABOR & DELIVERY
NURSING MOTHERS
PEDIATRIC USE
ANIMAL PHARMACOLOGY & OR TOXICOLOGY
VERAPAMIL HYDROCHLORIDE ADVERSE REACTIONS
WARNINGSWARNINGS
Treatment of acute cardiovascular adverse reactions
OVERDOSAGE
DOSAGE & ADMINISTRATION
Angina
Arrhythmias
PRECAUTIONS
Essential Hypertension
HOW SUPPLIED
STORAGE AND HANDLING
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL SECTION
Verapamil HydrochlorideVerapamil Hydrochloride TABLET
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PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
