Verapamil Hydrochloride
FULL PRESCRIBING INFORMATION: CONTENTS*
- VERAPAMIL HYDROCHLORIDE DESCRIPTION
- CLINICAL PHARMACOLOGY
- PHARMACOKINETICS AND METABOLISM
- INDICATIONS & USAGE
- VERAPAMIL HYDROCHLORIDE CONTRAINDICATIONS
- WARNINGS
- PRECAUTIONS
- DRUG INTERACTIONS
- CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY
- PREGNANCY
- LABOR & DELIVERY
- NURSING MOTHERS
- PEDIATRIC USE
- ANIMAL PHARMACOLOGY & OR TOXICOLOGY
- VERAPAMIL HYDROCHLORIDE ADVERSE REACTIONS
- OVERDOSAGE
- DOSAGE & ADMINISTRATION
- HOW SUPPLIED
- PACKAGE LABEL.PRINCIPAL DISPLAY PANEL SECTION
FULL PRESCRIBING INFORMATION
VERAPAMIL HYDROCHLORIDE DESCRIPTION
CLINICAL PHARMACOLOGY
Mechanism of Action
Essential Hypertension
Other Pharmacological Actions of Verapamil Include the Following
PHARMACOKINETICS AND METABOLISM
Hemodynamics and Myocardial Metabolism
Pulmonary Function
INDICATIONS & USAGE
VERAPAMIL HYDROCHLORIDE CONTRAINDICATIONS
WARNINGS
Heart FailureHypotension
Elevated Liver Enzymes
Accessory Bypass Tract (Wolff-Parkinson-White or Lown-Ganong-Levine)
Atrioventricular Block
Patients with Hypertrophic Cardiomyopathy (IHSS)
PRECAUTIONS
GeneralUse in Patients with Impaired Hepatic Function
Use in Patients with Attenuated (Decreased) Neuromuscular Transmission
Use in Patients with Impaired Renal Function
DRUG INTERACTIONS
TelithromycinClonidine
Cytochrome Inducers/Inhibitors
Aspirin
Grapefruit Juice
Beta-Blockers
Digitalis
Antihypertensive Agents
Antiarrhythmic Agents
Disopyramide
Flecainide
Quinidine
Nitrates
Other
Alcohol
Cimetidine
Lithium
Carbamazepine
Verapamil may increase carbamazepine concentrations during combined therapy. This may produce carbamazepine side effects such as diplopia, headache, ataxia, or dizziness.
Rifampin
Therapy with rifampin may markedly reduce oral verapamil bioavailability.
Phenobarbital
Phenobarbital therapy may increase verapamil clearance.
Cyclosporine
Verapamil therapy may increase serum levels of cyclosporine.
Theophylline
Verapamil therapy may inhibit the clearance and increase the plasma levels of theophylline.
Inhalation Anesthetics
Animal experiments have shown that inhalation anesthetics depress cardiovascular activity by decreasing the inward movement of calcium ions. When used concomitantly, inhalation anesthetics and calcium antagonists, such as verapamil, should each be titrated carefully to avoid excessive cardiovascular depression.
Neuromuscular-Blocking Agents
Clinical data and animal studies suggest that verapamil may potentiate the activity of neuromuscular blocking agents (curare-like and depolarizing). It may be necessary to decrease the dose of verapamil and/or the dose of the neuromuscular blocking agent when the drugs are used concomitantly.
CARCINOGENESIS & MUTAGENESIS & IMPAIRMENT OF FERTILITY
PREGNANCY
Pregnancy Category CLABOR & DELIVERY
NURSING MOTHERS
PEDIATRIC USE
ANIMAL PHARMACOLOGY & OR TOXICOLOGY
VERAPAMIL HYDROCHLORIDE ADVERSE REACTIONS
Treatment of Acute Cardiovascular Adverse Reactions
OVERDOSAGE
DOSAGE & ADMINISTRATION
Essential hypertensionHOW SUPPLIED
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL SECTION
Verapamil HydrochlorideVerapamil Hydrochloride TABLET, EXTENDED RELEASE
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PLEASE, BE CAREFUL!
Be sure to consult your doctor before taking any medication!
